Database : HANSEN Search on : PREDISPOSICAO GENETICA PARA DOENCA/*GE [Subject descriptor] References found : 5 [refine] Displaying: 1 .. 5   in format [Detailed]

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Id: 17691 Author: Scollard, D. M; Adams, L. B; Gillis, T. P; Krahenbuhl, J. L; Truman, R. W; Williams, D. L Title: The continuing challenges of leprosy ..- Source: s.l; s.n; 2006. 44 p. ilus, tab. Abstract: Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses in humans. The second is a peripheral neuropathy that is initiated by the infection and the accompanying immunological events. The infection is curable but not preventable, and leprosy remains a major global health problem, especially in the developing world, publicity to the contrary notwithstanding. Mycobacterium leprae remains noncultivable, and for over a century leprosy has presented major challenges in the fields of microbiology, pathology, immunology, and genetics; it continues to do so today. This review focuses on recent advances in our understanding of M. leprae and the host response to it, especially concerning molecular identification of M. leprae, knowledge of its genome, transcriptome, and proteome, its mechanisms of microbial resistance, and recognition of strains by variable-number tandem repeat analysis. Advances in experimental models include studies in gene knockout mice and the development of molecular techniques to explore the armadillo model. In clinical studies, notable progress has been made concerning the immunology and immunopathology of leprosy, the genetics of human resistance, mechanisms of nerve injury, and chemotherapy. In nearly all of these areas, however, leprosy remains poorly understood compared to other major bacterial diseases. (AU). Descriptors: Antiinfecciosos/TU Proteínas de Bactérias/ME Vacinas Bacterianas Modelos Animais de Doenças Suscetibilidade à Doença/IM Resistência Bacteriana a Drogas Genes Bacterianos/GE Predisposição Genética para Doença Genoma Bacteriano Imunidade Celular Imunidade Natural/GE Hansenostáticos/PD/TU Hanseníase/*/DI/MI/TH Mycobacterium leprae/*/CH/DE/IP/PH Nervos Periféricos/MI Doenças do Sistema Nervoso Periférico/MI/PA Reação em Cadeia da Polimerase Research Support, N.I.H., Extramural Células de Schwann/IM/MI Limits: HUMANO ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Location: BR191.1; 09365/S

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Id: 17287 Author: Engers, H; Morel, C. M Title: Leprosy ..- Source: s.l; s.n; 2003. 2 p. mapas. Descriptors: Antituberculosos/TU Predisposição Genética para Doença Hanseníase/*/DI/DT/EP/GE Mycobacterium leprae/GE Organização Mundial da Saúde Limits: Humano Location: BR191.1; 00252/s

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Id: 17277 Author: Mohammad, Hatta Title: Epidemiology of leprosy: molecular, biological, and immunological approach ..- Source: s.l; s.n; 2003. 10 p. tab. Abstract: Leprosy is an infectious disease for which humans are considered the only source of infection. The major hindrance in leprosy control and thus in reaching the elimination goal is that numerous leprosy cases remain undetected for a long time. Many of these patients are a continuous source of infection and, and hence perpetuate transmission. The goal of the World Health Organization (WHO) is to eliminate leprosy as a public problem by the year 2000; that is, to reach as a global prevalence of <1 per 10,000 people. The epidemiological data generated routinely by health services are greatly influenced by their policies and activities. The data do not, however necessarily reflect the true situation in the field. Information on the magnitude of the leprosy problem in any one area is important for the health services with regard to their planning, monitoring and evaluation of leprosy control activities. Our studies have suggested that the high prevalence of antibodies in children may be indicative of the active transmission of M. leprae in their surroundings. The prevalence of these antibodies may also be important for leprosy control programs in order to detect new patients as early as possible and in an effective and sustainable manner. Based on PCR data, it seems that the environment also plays an important role in the transmission of leprosy in endemic areas. The results of our study show that contact with a leprosy patient is the major determinant in the incidence of leprosy and that this concept shows similarities with the "stone-in-the-pond" principle of tuberculosis transmission in concentric circle around patients. (AU). Descriptors: Anticorpos Análise por Conglomerados DNA Bacteriano Predisposição Genética para Doença/*GE Geografia Incidência Hanseníase/BL/*EP/TM Mycobacterium leprae/GE/*PY Prevalência Estudos Soroepidemiológicos Limits: Humano Location: BR191.1; 09176/s

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Id: 12295 Author: Meisner, Sarah J; Mucklow, Stuart; Warner, Giles; Sow, Samba O; Lienhardt, Christian; Hill, Adrian V. S Title: Association of NRAMP1 polymorphism with leprosy type but not susceptibility to leprosy per se in West Africans ..- Source: s.l; s.n; 2001. 3 p. tab. Descriptors: ESTUDOS DE CASOS E CONTROLES GENOTIPO HANSENIASE HANSENIASE MALI RAÇA NEGRA POLIMORFISMO (GENÉTICA) PROTEINAS TRANSPORTADORAS DE CATIONS/*GE PREDISPOSICAO GENETICA PARA DOENCA/*GE Location: BR191.1; 08664/s

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Id: 10357 Author: Levin, Michael; Newport, Melanie Title: Understanding the genetic basis of susceptibility to mycobacterial infection ..- Source: s.l; s.n; 1999. 5 p. . Descriptors: CRIANÇA GAMBIA IMUNIDADE NATURAL HANSENIASE MALTA CAMUNDONGOS MICOBACTERIOSE RECEPTORES DE INTERFERON TUBERCULOSE PREDISPOSICAO GENETICA PARA DOENCA/*GE Location: BR191.1; 07474/s

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